Posted by: shrikantmantri | January 27, 2010

Cooperation of Multiple Chromatin Modifications Can Generate Unanticipated Stability of Epigenetic States in Arabidopsis.

Cooperation of Multiple Chromatin Modifications Can Generate Unanticipated Stability of Epigenetic States in Arabidopsis.

Publication Date: 2010 Jan 22 PMID: 20097869
Authors: Baubec, T. – Dinh, H. Q. – Pecinka, A. – Rakic, B. – Rozhon, W. – Wohlrab, B. – von Haeseler, A. – Scheid, O. M.
Journal: Plant Cell

Epigenetic changes of gene expression can potentially be reversed by developmental programs, genetic manipulation, or pharmacological interference. However, a case of transcriptional gene silencing, originally observed in tetraploid Arabidopsis thaliana plants, created an epiallele resistant to many mutations or inhibitor treatments that activate many other suppressed genes. This raised the question about the molecular basis of this extreme stability. A combination of forward and reverse genetics and drug application provides evidence for an epigenetic double lock that is only alleviated upon the simultaneous removal of both DNA methylation and histone methylation. Therefore, the cooperation of multiple chromatin modifications can generate unanticipated stability of epigenetic states and contributes to heritable diversity of gene expression patterns.

Posted via email from Sharing significant bytes —(Shrikant Mantri)

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