Posted by: shrikantmantri | January 22, 2010

Science Paper: Evolution of MRSA During Hospital Transmission and Intercontinental Spread

Evolution of MRSA During Hospital Transmission and Intercontinental Spread

Simon R. Harris,1,* Edward J. Feil,2,* Matthew T. G. Holden,1 Michael A. Quail,1 Emma K. Nickerson,3,4 Narisara Chantratita,3 Susana Gardete,5,6 Ana Tavares,5 Nick Day,3,7 Jodi A. Lindsay,8 Jonathan D. Edgeworth,9,10 Hermínia de Lencastre,5,6 Julian Parkhill,1 Sharon J. Peacock,3,4 Stephen D. Bentley1,{dagger}

Current methods for differentiating isolates of predominant lineages of pathogenic bacteria often do not provide sufficient resolution to define precise relationships. Here, we describe a high-throughput genomics approach that provides a high-resolution view of the epidemiology and microevolution of a dominant strain of methicillin-resistant Staphylococcus aureus (MRSA). This approach reveals the global geographic structure within the lineage, its intercontinental transmission through four decades, and the potential to trace person-to-person transmission within a hospital environment. The ability to interrogate and resolve bacterial populations is applicable to a range of infectious diseases, as well as microbial ecology.

1 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 15A, UK.
2 Department of Biology and Biochemistry, University of Bath, South Building, Claverton Down, Bath BA2 7AY, UK.
3 Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
4 Department of Medicine, University of Cambridge, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK.
5 Laboratory of Molecular Genetics, Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, 2780-156 Oeiras, Portugal.
6 Laboratory of Microbiology, The Rockefeller University, New York, NY 10065, USA.
7 Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7LJ, UK.
8 Centre for Infection, Department of Cellular and Molecular Medicine, St. George’s, University of London, Cranmer Terrace, London SW17 0RE, UK.
9 Department of Infectious Diseases, King’s College London, Guy’s, King’s, and St. Thomas’ Medical School, Guy’s Hospital, London SE1 9RT, UK.
10 Directorate of Infection, Guy’s and St. Thomas’ National Health Service Foundation Trust, London SE1 7EH, UK. * These authors contributed equally to this work.

Posted via email from Sharing significant bytes —(Shrikant Mantri)


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