Posted by: shrikantmantri | December 26, 2009

Rational design of a structural and functional nitric oxide reductase

Rational design of a structural and functional nitric oxide reductase p1079

Despite the progress that has been made in designing proteins that mimic native proteins structurally, it is difficult to design functional proteins and particularly challenging to design metalloproteins that reproduce both the structure and function of native metalloenzymes. Here, the successful, rational design of a structural and functional model of a metalloprotein — nitric oxide reductase — is achieved.

Natasha Yeung, Ying-Wu Lin, Yi-Gui Gao, Xuan Zhao, Brandy S. Russell, Lanyu Lei, Kyle D. Miner, Howard Robinson & Yi Lu

doi:10.1038/nature08620

Posted via email from Sharing significant bytes —(Shrikant Mantri)

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